Guideline Commentaries

Commentary on  NICE Clinical Practice Guidelines

Tolvaptan for treating autosomal dominant polycystic kidney disease (2016)

In October 2015, NICE recommended that Tolvaptan (JINARC®) therapy should be made available for selected patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) in England and Wales In January 2016, the Scottish Medicines Consortium (SMC) also approved Tolvaptan for use in Scotland. Currently Tolvaptan is being used in Canada, Japan, Korea and Switzerland for ADPKD and has been approved for use in Europe by the European Medicines Agency (EMA).  NICE recommended that patients with ADPKD who may be eligible for treatment must have Stage 2 or 3 chronic kidney disease (CKD) and ‘evidence of rapidly progressing disease’. SMC have approved its use for Stages 1-3 CKD, similar to that recommended by the EMA. The definition and evaluation of ‘rapid progression’ are however not established and have not been stipulated by NICE, SMC or the EMA.  The main purpose of this commentary is to address the issue of how to identify patients with evidence of or who are at risk of rapid disease progression.

Commentary on KDIGO Clinical Practice Guidelines

The Renal Association provides a commentary on the relevance and utility of KDIGO guidelines to UK practice

 Treatment of Glomerulonephritis (2013)
Management of the kidney transplant recipient in the UK

Hepatitis C 

Chronic Kidney Disease – Mineral and Bone Disorder (2009)

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